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By pure definitions, I feel, one is the study based on computer simulations and other the experiments. AnimeshIndian Statistical Institute
Again from the same philosophy of verbal expression:-Molecular Systems BiologyMolecular Scale: At the molecular level there are physical properties (you cansay as processes) and hence the chemical properties.I feel all chemistry is amanifestation of physics.Systems: An orthogonal view is component-level (molecular-level). However at thesystem's level especially when you are collectively sayin 'Molecular systems',it means integrated dynamic(behavioural) and static(structural)analysis/analysis of segregated molecular processes(forming the system).So in all if you coin Molecular Systems Biology.While Computational Systems Biology (CSB)Systems--> When you say systems (a pure unambiguous term) meaning some input/stimuli (biologically speaking) produces some output (response). However ifthe system is robust, we may not see any output/ response (biologicallyspeaking). In that case this input may be captured by some internal propertiesof the system.Systems Biology: If you take the systems components to be some biologicalprocesses.When you add the term of Computational it becomes the automated analysesinvolving the databasing of experimental data, then makingmodels/simulations/validations by employing some computation. However this CSBcan have degenerated standpoints because bilogy has got several finestandpoints. This computation could be simple software or could be a complexalgorithm borrowed from computersciences.Finally I feel like CSB encapsulates MSB, because MSB is present in CSB as stored data and/or knowledge.Disclaimer: Its my personal understanding of terminology rather axioms based onmy vocabulary inference. This is replied as a thought.
I thank two of the posts from Animesh and Gourinath.I feel that computational systems biology is a take from molecular systems biology as biology might have reckoned "molecules" first, then the whole system. Owing to data deluge, we have raised computational systems biology through computational biology. In conclusion, this impeccable subject has much to do to peg thoughts on number of orphan genes in the organisms.ThanksPrash
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